Deletion of <i>Lkb1</i> in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

Abstract

Our findings demonstrate that LKB1 in hypothalamic POMC neurons plays a key role in the central regulation of peripheral glucose metabolism but not body-weight control. This phenotype contrasts with that seen in mice lacking AMPK in POMC neurons with defects in body-weight regulation but not glucose homeostasis, which suggests that LKB1 plays additional functions distinct from activating AMPK in POMC neurons.