Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Colin Selman, Jennifer M. A. Tullet, Daniela Wieser, +19

Science

Anti-agingMolecular RegulationCell DeathCell CycleCaloric Restriction +20

Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice

Colin Selman, Steven J. Lingard, Agharul I. Choudhury, +16

The FASEB Journal

Null MiceAnti-agingAgingInsulin ReceptorBiogerontology +16

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

Marc Claret, Mark A. Smith, Rachel L. Batterham, +14

Journal of Clinical Investigation

The role of insulin receptor substrate 2 in hypothalamic and β cell function

Agharul I. Choudhury, Helen Heffron, Mark A. Smith, +17

Journal of Clinical Investigation

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons

Hind Al‐Qassab, Mark A. Smith, Elaine E. Irvine, +15

Cell Metabolism

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

Richard Killick, Georgie Scales, Karelle Leroy, +13

Biochemical and Biophysical Research Communications

Brain Deletion of Insulin Receptor Substrate 2 Disrupts Hippocampal Synaptic Plasticity and Metaplasticity

Derek A. Costello, Marc Claret, Hind Al‐Qassab, +6

PLoS ONE

Melanocortins and agouti‐related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances

Mark A. Smith, Kazunari Hisadome, Hind Al‐Qassab, +3

The Journal of Physiology

Synaptic TransmissionNeurotransmissionHypothalamic CircuitsSynaptic SignalingSensory Systems +22

Insulin receptor substrate 2 is a negative regulator of memory formation

Elaine E. Irvine, Laura Drinkwater, Kasia Radwańska, +8

Learning & Memory

Deletion of <i>Lkb1</i> in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

Marc Claret, Mark A. Smith, Claude Knauf, +20

Diabetes