Neuro-Oncology · 2013 · 96 citations · 48 references
MedicineOncologyPharmacologyNeuro-oncologyPharmacokinetics Of Anticancer AgentsTumor ProgressionBrain TumorsCancer ProgressionCentral Nervous System Tumor PharmacotherapyGlioblastomaPharmacokinetics Of Anticancer DrugsToxicity ManagementEpidermal Growth Factor Receptor InhibitionEpidermal Growth Factor Receptor SignalingErlotinib TherapyGlioblastoma Clinical TrialsGlioblastoma Drug TherapyGlioblastoma TrialsPharmacokinetic Study DesignSorafenib Therapy
BACKGROUND: The signal transduction pathways of epidermal growth factor receptor and Ras are both important in the growth of glioblastoma multiforme (GBM). We hypothesized that inhibition of both pathways would improve the survival time of patients with recurrent GBM. METHODS: Patients with recurrent/progressive GBM with 0-2 prior chemotherapy regimens received erlotinib 150 mg once daily and sorafenib 400 mg twice daily until progression. The primary endpoint was overall survival. Pharmacokinetic sampling was performed during cycle 1. RESULTS: The median overall survival was 5.7 months. Progression-free survival at 6 months was 14%. Toxicity was manageable. Clearance of erlotinib was markedly enhanced by sorafenib. CONCLUSION: The study did not meet its objective of a 30% increase in overall survival time compared with historical controls. Erlotinib and sorafenib have significant pharmacokinetic interactions that may negatively impact the efficacy of the combination regimen.
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Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Roger Stupp, Warren Mason, Martin J. van den Bent et al. · New England Journal of Medicine · 2005 · 21.6K citations · Full text
Response criteria for phase II studies of supratentorial malignant glioma.
David R. Macdonald, T L Cascino, S. Clifford Schold et al. · Journal of Clinical Oncology · 1990 · 2.4K citations