Concepedia

Intravenous Calcium and Magnesium for Oxaliplatin-Induced Sensory Neurotoxicity in Adjuvant Colon Cancer: NCCTG N04C7

Axel Grothey, Daniel A. Nikcevich, Jeff A. Sloan, John W. Kugler, Peter T. Silberstein, Todor Dentchev, Donald B. Wender, Paul J. Novotny, Umesh Chitaley, Steven R. Alberts,

Journal of Clinical Oncology · 2010 · 195 citations · 12 references

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Abstract

Despite early termination and decreased statistical power, this study supports IV Ca/Mg as an effective neuroprotectant against oxaliplatin-induced cumulative sNT in adjuvant colon cancer.

References

12

Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer

Aimery de Gramont, Arié Figer, Michel Seymour et al. · Journal of Clinical Oncology · 2000 · 3.8K citations

Oxaliplatin, Fluorouracil, and Leucovorin as Adjuvant Treatment for Colon Cancer

Thierry André, C. Boni, Lamia Mounedji-Boudiaf et al. · New England Journal of Medicine · 2004 · 3.6K citations · Full text

Chronomodulated Versus Fixed-Infusion—Rate Delivery of Ambulatory Chemotherapy With Oxaliplatin, Fluorouracil, and Folinic Acid (Leucovorin) in Patients With Colorectal Cancer Metastases: a Randomized Multi-institutional Trial

Françis Lévi, Rachid Zidani, Jean-Michel Vannetzel et al. · JNCI Journal of the National Cancer Institute · 1994 · 389 citations

Prevention of Oxaliplatin-Related Neurotoxicity by Calcium and Magnesium Infusions

Laurence Gamelin, M. Boisdron‐Celle, R. Delva et al. · Clinical Cancer Research · 2004 · 342 citations · Full text

A Possible Explanation for a Neurotoxic Effect of the Anticancer Agent Oxaliplatin on Neuronal Voltage-Gated Sodium Channels

Françoise Grolleau, Laurence Gamelin, M. Boisdron‐Celle et al. · Journal of Neurophysiology · 2001 · 337 citations

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