Chronomodulated Versus Fixed-Infusion—Rate Delivery of Ambulatory Chemotherapy With Oxaliplatin, Fluorouracil, and Folinic Acid (Leucovorin) in Patients With Colorectal Cancer Metastases: a Randomized Multi-institutional Trial - Concepedia

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Chronomodulated Versus Fixed-Infusion—Rate Delivery of Ambulatory Chemotherapy With Oxaliplatin, Fluorouracil, and Folinic Acid (Leucovorin) in Patients With Colorectal Cancer Metastases: a Randomized Multi-institutional Trial

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References

1994

Year

Françis Lévi, Rachid Zidani, Jean-Michel Vannetzel, B Perpoint, Christian Focan, R. Faggiuolo, P. Chollet, Carlo Garufi, M. Itzhaki, Luigi Dogliotti,

JNCI Journal of the National Cancer Institute

Abstract

The respective roles of 1-OHP dose and schedule and circadian peak time of drug delivery are being investigated with regard to the high activity of this three-drug, chronomodulated chemotherapeutic regimen.