Concepedia

Human Neutrophil Elastase Degrades SPLUNC1 and Impairs Airway Epithelial Defense against Bacteria

Di Jiang, Sally E. Wenzel, Qun Wu, Russell P. Bowler, Christina Schnell, Hong Wei Chu

PLoS ONE · 2013 · 52 citations · 30 references

Open access

Abstract

Our findings suggest that SPLUNC1 degradation by neutrophil elastase may increase airway susceptibility to bacterial infections. SPLUNC1 therapy likely attenuates bacterial infections during AECOPD.

References

30

<i>Moraxella catarrhalis</i> in Chronic Obstructive Pulmonary Disease

Timothy F. Murphy, Aimee L. Brauer, Brydon J. B. Grant et al. · American Journal of Respiratory and Critical Care Medicine · 2005 · 290 citations · Full text

Association between markers of emphysema and more severe chronic obstructive pulmonary disease

Piera Boschetto, Sonia Quintavalle, Elena Zeni et al. · Thorax · 2006 · 165 citations · Full text

Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae

Haa Yung Lee, Ali Andalibi, Paul Webster et al. · BMC Infectious Diseases · 2004 · 144 citations · Full text

Function and Regulation of SPLUNC1 Protein in Mycoplasma Infection and Allergic Inflammation

Hong Wei Chu, Jyoti Thaikoottathil, John G. Rino et al. · The Journal of Immunology · 2007 · 129 citations · Full text

LL-37 Complexation with Glycosaminoglycans in Cystic Fibrosis Lungs Inhibits Antimicrobial Activity, Which Can Be Restored by Hypertonic Saline

Gudmundur Bergsson, Emer P. Reeves, Paul McNally et al. · The Journal of Immunology · 2009 · 129 citations