Stimulation of Sigma Receptors with Afobazole Blocks Activation of Microglia and Reduces Toxicity Caused by Amyloid-β25–35

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

George G. Glenner, Caine W. Wong · Biochemical and Biophysical Research Communications · 1984 · 5.4K citations

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Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

Ana Griciuc, Alberto Serrano‐Pozo, Antonio Parrado et al. · Neuron · 2013 · 1K citations · Full text

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A proposal for the classification of sigma binding sites

Rémi Quirion, Wayne D. Bowen, Yossef Itzhak et al. · Trends in Pharmacological Sciences · 1992 · 754 citations

Pharmacy, Molecular Biology, Molecular Recognition +7

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

Wolfgang J. Streit, Heiko Braak, Qing‐Shan Xue et al. · Acta Neuropathologica · 2009 · 745 citations · Full text

Medicine, Neurobiology, Neuroscience +17

β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis

Colin K. Combs, J. Colleen Karlo, Shih-Chu Kao et al. · Journal of Neuroscience · 2001 · 729 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17