Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration

Paraoxonase prevents accumulation of lipoperoxides in low‐density lipoprotein

Michael I. Mackness, Sharon Arrol, Paul N. Durrington · FEBS Letters · 1991 · 978 citations

Life Sciences, Biochemistry, Lipid Biochemistry +16

The molecular basis of the human serum paraoxonase activity polymorphism

Richard Humbert, David A. Adler, Christine M. Distèche et al. · Nature Genetics · 1993 · 840 citations

Life Sciences, Biochemistry, Genetics +4

Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase

M MACKNESS, Sharon Arrol, Caroline A. Abbott et al. · Atherosclerosis · 1993 · 816 citations

Life Sciences, Biochemistry, Lipid Biochemistry +14

Genetic Association of Apolipoprotein E with Age-Related Macular Degeneration

Caroline C. W. Klaver, Mike Kliffen, Cornelia M. van Duijn et al. · The American Journal of Human Genetics · 1998 · 492 citations · Full text

Medicine, Genetics, Ophthalmology +16

Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes.

M C Garin, Richard W. James, Philippe Dussoix et al. · Journal of Clinical Investigation · 1997 · 478 citations · Full text

Medicine, Genetics, Molecular Genetics +11