Antimicrobial Agents and Chemotherapy · 1999 · 68 citations · 28 references
Life SciencesMicrobiologyMolecular GeneticsAntimicrobial ResistanceMedical MicrobiologyMicrobial GeneticsAntibiotic ResistanceAntibiotic Resistance GeneticsAntibiotic Resistance MechanismsMechanisms Of Antimicrobial ResistanceResistance GenesResistance In Gram-positive BacteriaAntimicrobial Resistance In Enteric PathogensEfflux-mediated Fluoroquinolone ResistanceEnterococciFluoroquinolone AntibioticsFluoroquinolone Resistance MechanismsQuinolone Resistance MechanismsResistance Mechanisms In EnterococciResistance Mechanisms In Gram-positive Bacteria
High-level quinolone resistance in Enterococcus faecium was associated with mutations in both gyrA and parC genes in 10 of 11 resistant strains. On low-level resistant strain without such mutations may instead possess an efflux mechanism or alterations in the other subunits of the gyrase or topoisomerase IV genes. These findings are similar to those for other gram-positive bacteria, such as Enterococcus faecalis.
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