Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · 2000 · 66 citations · 5 references
MedicinePharmacokineticsPharmacologyClinical PharmacologyDrug InteractionsDrug MetabolismAntiretroviral TherapyAntiviral PharmacologyAntiviral TherapyCytochrome P450 InteractionsDrug-drug Interactions In MetabolismPharmacokinetic Drug InteractionsAntiretroviral InteractionsCyp450-mediated InteractionsMethadone Drug InteractionsMethadone Maintenance TherapyMethadone Maintenance TreatmentPharmacokinetics Of Antiretroviral DrugsProtease InhibitorsWithdrawal Symptoms
Combination antiretroviral therapy including protease inhibitors such as ritonavir has added significant potency to therapy for human immunodeficiency viral (HIV) infection as well as substantial drug-drug interactions. Methadone metabolism is affected by cytochrome P450 (CYP) 3A4 inhibitors or inducers. Because ritonavir can induce CYP3A, it can decrease methadone plasma levels. An HIV-infected patient receiving methadone maintenance experienced withdrawal symptoms after ritonavir, saquinavir, and stavudine were added to his regimen; the most likely cause was ritonavir.
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Inhibition of methadone and buprenorphine N-dealkylations by three HIV-1 protease inhibitors.
Christelle Iribarne, F. Berthou, D Carlhant et al. · PubMed · 1998 · 125 citations
Cimetidine inhibits the in vitro N-demethylation of methadone.