Suppression of Cytokines and Nitric Oxide Production, and Protection Against Lethal Endotoxemia and Viral Myocarditis by a New NF-κB Inhibitor

Abstract

These findings suggest that the activation of NF-kappaB plays an important role in the pathogenesis of endotoxemia and viral myocarditis, and that the NF-kappaB inhibitor, SUN C8079, may be therapeutic in these disorders.