Ruthenium complexes as novel inhibitors of human islet amyloid polypeptide fibril formation

Abstract

Human islet amyloid polypeptide (hIAPP) can be linked to the pathology of type II diabetes. In this study, aromatic ring-containing Ru complexes were found to effectively inhibit the fibril formation of hIAPP and promote the disaggregation of formed fibrils by remarkably changing the β-sheet components.