PubMed · 2010 · 107 citations · 15 references
MedicineNeurologyNeuroscienceFlow VisualizationFluid DynamicsNeuroimmunologyCerebral Blood FlowCerebrovascular PhysiologyChronic Venous InsufficiencyMultiple SclerosisNeurovascular AssessmentNeurovascular DysfunctionCerebral Blood Flow QuantificationCerebral Pressure-flow RelationshipsVascular Flow Velocity MeasurementVenous Doppler EvaluationVenous Hemodynamic Assessment
Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular picture that shows a strong association with multiple sclerosis (MS). The aim of this study was to investigate the relationship between a Doppler cerebral venous hemodynamic insufficiency severity score (VHISS) and cerebrospinal fluid (CSF) flow dynamics in 16 patients presenting with CCSVI and relapsing-remitting MS (CCSVI-MS) and in eight healthy controls (HCs). The two groups (patients and controls) were evaluated using validated echo-Doppler and advanced 3T-MRI CSF flow measures. Compared with the HCs, the CCSVI-MS patients showed a significantly lower net CSF flow (p=0.027) which was highly associated with the VHISS (r=0.8280, r2=0.6855; p=0.0001). This study demonstrates that venous outflow disturbances in the form of CCSVI significantly impact on CSF pathophysiology in patients with MS.
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Rating neurologic impairment in multiple sclerosis
John F. Kurtzke · Neurology · 1983 · 14.9K citations
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