Cleveland Clinic Journal of Medicine · 2014 · 26 citations · 19 references
PharmacyInfectious DiseasesPharmacotherapyHepatitis PharmacotherapyMolecular VirologyVirologyAntiviral AgentsAntiviral PharmacologyAntiviral PharmacotherapyAntiviral TherapyViral HepatitisViral Hepatitis TreatmentCombination Antiviral RegimensDirect-acting Antiviral AgentsDirect-acting AntiviralsHepatitis C InfectionTherapeutic Antiviral Therapy
Treatment for chronic hepatitis C virus (HCV) infection is evolving rapidly. The approval in 2013 of two new direct-acting antivirals-sofosbuvir (a polymerase inhibitor) and simeprevir (a second-generation protease inhibitor)-opens the door for an all-oral regimen, potentially avoiding interferon and its harsh side effects. Other direct-acting antivirals are under development.
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Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection
Eric Lawitz, Alessandra Mangia, David Wyles et al. · New England Journal of Medicine · 2013 · 1.8K citations
Marc G. Ghany, David R. Nelson, Doris B. Strader et al. · Hepatology · 2011 · 1.1K citations · Full text