First Stereoselective Syntheses of (−)-Siphonodiol and (−)-Tetrahydrosiphonodiol, Bioactive Polyacetylenes from Marine Sponges

Abstract

The first stereoselective total syntheses of the bioactive marine polyacetylenes (-)-siphonodiol and (-)-tetrahydrosiphonodiol were achieved using highly convergent approaches based on optimized Cadiot-Chodkiewicz and sequential Sonogashira cross-coupling reactions.