Concepedia

Physiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous Doses

Guy Meno‐Tetang, Hongshan Li, Suzette M. Mis, Nancy A. Pyszczynski, Peter Heining, Philip J. Lowe, William J. Jusko

Drug Metabolism and Disposition · 2006 · 132 citations · 12 references

DOI

Concepts

References

12

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

Kenji Chiba, Yoshiki Yanagawa, Yumi Masubuchi et al. · The Journal of Immunology · 1998 · 596 citations

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FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. II. FTY720 Prolongs Skin Allograft Survival by Decreasing T Cell Infiltration into Grafts But Not Cytokine Production In Vivo

Yoshiki Yanagawa, Kunio Sugahara, Hirotoshi Kataoka et al. · The Journal of Immunology · 1998 · 262 citations · Full text

, , +16

Physiologic modeling of cyclosporin kinetics in rat and man

A. Bernareggi, Malcolm Rowland · Journal of Pharmacokinetics and Biopharmaceutics · 1991 · 177 citations

, , +12

FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation

Volker Brinkmann, Daniel D. Pinschewer, Kenji Chiba et al. · Trends in Pharmacological Sciences · 2000 · 167 citations

, , +13

Immunosuppressant FTY720 inhibits thymocyte emigration

Hideki Yagi, Rikiya Kamba, Kenji Chiba et al. · European Journal of Immunology · 2000 · 135 citations

, , +13