Handedness and hemispheric language dominance in healthy humans

TLDR

Language is typically left‑hemisphere dominant, yet left‑handed individuals exhibit a higher incidence of right‑hemisphere dominance, indicating a link between handedness and language lateralization. The study aimed to clarify how handedness relates to language dominance by measuring lateralization in 326 healthy participants with functional transcranial Doppler during a word‑generation task. Lateralization was assessed via functional transcranial Doppler sonography during a word‑generation task in 326 healthy subjects. Right‑hemisphere language dominance rose linearly with left‑handedness—from 4 % in strong right‑handers to 27 % in strong left‑handers—demonstrating a natural, non‑pathological relationship between handedness and language lateralization.

Abstract

In most people the left hemisphere of the brain is dominant for language. Because of the increased incidence of atypical right-hemispheric language in left-handed neurological patients, a systematic association between handedness and dominance has long been suspected. To clarify the relationship between handedness and language dominance in healthy subjects, we measured lateralization directly by functional transcranial Doppler sonography in 326 healthy individuals using a word-generation task. The incidence of right-hemisphere language dominance was found to increase linearly with the degree of left-handedness, from 4% in strong right-handers (handedness = 100) to 15% in ambidextrous individuals and 27% in strong left-handers (handedness = -100). The relationship could be approximated by the formula: f1.gif" BORDER="0">. These results clearly demonstrate that the relationship between handedness and language dominance is not an artefact of cerebral pathology but a natural phenomenon.