Organic Letters · 2002 · 31 citations · 9 references
Natural SciencesChemical EngineeringChemistryElectrochemical EngineeringElectrochemistryOrganic ChemistryElectrochemical CellsElectrochemical SynthesisElectrolysis ProcessesHeterocycle SynthesisHeterocyclic ChemistryMacrocycle SynthesisAnodic SynthesisConjugate AdditionElectrochemical CyclizationElectrocyclic ReactionsFuran ChemistryFuran SynthesisFuransFused Heterocycle Synthesis
[reaction: see text] A two-step electrochemical annulation has been developed for the preparation of fused furans. The process involves an initial conjugate addition of a furyethyl cuprate and trapping of the enolate as the corresponding silyl enolether. The second step of the annulation involves the anodic coupling of the furan and the silyl enol ether to form a six-membered ring.
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