E‐Selectin‐Targeted Porous Silicon Particle for Nanoparticle Delivery to the Bone Marrow

Abstract

A multifunctional drug delivery system is developed comprising biodegradable porous silicon microparticles that act as motherships to ferry different types of imaging and therapeutic nanoparticles loaded within their porous structure. An E-selectin thioaptamer ligand is used to actively target this delivery system to the bone marrow vasculature where the payload is released as the porous silicon underwent degradation under physiological conditions. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.