Angiotensin Receptor–Binding Protein ATRAP/ <i>Agtrap</i> Inhibits Metabolic Dysfunction With Visceral Obesity

Abstract

These results demonstrate that Agtrap(-/-) mice are an effective model of metabolic disorders with visceral obesity and constitute evidence that ATRAP plays a protective role against insulin resistance, suggesting a new therapeutic target in metabolic disorders. Identification of ATRAP as a novel receptor binding modulator of adipose tissue inflammation not only has cardiovascular significance but may have generalized implication in the regulation of tissue function.