Fluorescent Epibatidine Agonists for Neuronal and Muscle‐Type Nicotinic Acetylcholine Receptors

Abstract

Singled out: Specific high-affinity binding to and activation of nicotinic acetylcholine receptors (nAChRs) by fluorescent epibatidine (EPB) agonists is detected by fluorescence microscopy and electrophysiology (see picture). The optical and pharmacological properties of these compounds allow single-channel/single-molecule experiments at the surface of living cells, and investigation of channel gating and receptor trafficking. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604807_s.html or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.