Piezo proteins are pore-forming subunits of mechanically activated channels

Bertrand Coste, Bailong Xiao, Jose S. Santos, +9

Nature

Protein SecretionMolecular PhysiologySignal TransductionMolecular BiologyPiezo Proteins +5

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

Whasil Lee, Holly A. Leddy, Yong Chen, +11

Proceedings of the National Academy of Sciences

Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

Amanda H. Lewis, Jörg Grandl

eLife

Membrane StructureEngineeringCytoskeletonMechanotransductionBiomedical Engineering +18

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

Jörg Grandl, Sung Eun Kim, Valerie Uzzell, +4

Nature Neuroscience

Pore DomainMembrane TransportTrpv1 Ion ChannelApplied PhysicsPorous Membrane +5

Pore region of TRPV3 ion channel is specifically required for heat activation

Jörg Grandl, Hongzhen Hu, Michael Bandell, +4

Nature Neuroscience

Trpv3 Ion ChannelEngineeringPore RegionApplied PhysicsIon Channels +5

Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes

Liang-Fu Chen, Yen Ting Lin, David A. Gallegos, +10

Cell Reports

Histone AcetylationEpigenetic ChangeFos TranscriptionNeurotransmissionEpigenetics +18

Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization

Adrienne E. Dubin, Swetha E. Murthy, Amanda H. Lewis, +5

Neuron

Endogenous Piezo1EngineeringBioelectronicsIon ChannelsElectrophysiology +5

Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels

Amanda H. Lewis, Alisa F. Cui, Malcolm F. McDonald, +1

Cell Reports

Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4

Hongzhen Hu, Jörg Grandl, Michael Bandell, +2

Proceedings of the National Academy of Sciences

Signal RecognitionMolecular BiologyCellular Physiology2-Apb ActivationTrp Box +16

Localized force application reveals mechanically sensitive domains of Piezo1

Jason Wu, Raman Goyal, Jörg Grandl

Nature Communications