Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells

Abstract

Our previous finding that 3-NC down regulates Inhibitor of Apoptosis Proteins (IAPs) and the present observation that Bax is upregulated and Bcl2 is down regulated upon 3-NC treatment, this chromene derivative has the potential to overcome chemotherapy resistance caused by up regulation of these proteins.