Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

Luis Ulloa, Jacqueline Doody, Joan Massagué · Nature · 1999 · 808 citations

Life Sciences, Cell Biology, Molecular Biology +13

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion

Zhimin Lu, Sourav Ghosh, Zhiyong Wang et al. · Cancer Cell · 2003 · 649 citations · Full text

Life Sciences, Cancer Biology, Cell Biology +16

Biochemical and Clinical Implications of the ErbB/HER Signaling Network of Growth Factor Receptors

Leah N. Klapper, Mark Kirschbaum, Michael Seta et al. · Advances in cancer research · 1999 · 546 citations

Life Sciences, Biochemistry, Molecular Biology +16

Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

Yibin Kang, Wei He, Shaun Tulley et al. · Proceedings of the National Academy of Sciences · 2005 · 533 citations · Full text

Medicine, Molecular Biology, Oncology +17

The Tumor Suppressor Smad4 Is Required for Transforming Growth Factor β–Induced Epithelial to Mesenchymal Transition and Bone Metastasis of Breast Cancer Cells

Martine Deckers, Maarten van Dinther, Jeroen T. Buijs et al. · Cancer Research · 2006 · 376 citations

Medicine, Cancer Biology, Oncology +17