Concepedia

Prospective Multicentric Randomized Phase III Study of Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors Comparing Interruption Versus Continuation of Treatment Beyond 1 Year: The French Sarcoma Group

Jean‐Yves Blay, Axel Le Cesne, Isabelle Ray‐Coquard, Binh Bui, Florence Duffaud, Catherine Delbaldo, Antoine Adenis, Patrice Viens, María Rios, Emmanuelle Bompas,

Journal of Clinical Oncology · 2007 · 390 citations · 21 references

DOI

Abstract

Imatinib interruption results in rapid progression in most patients with advanced GIST, and cannot be recommended in routine practice unless patient experience significant toxicity

References

21

Gain-of-Function Mutations of c- <i>kit</i> in Human Gastrointestinal Stromal Tumors

Seiichi Hirota, Koji Isozaki, Y Moriyama et al. · Science · 1998 · 4.4K citations

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

George D. Demetri, Margaret von Mehren, Charles D. Blanke et al. · New England Journal of Medicine · 2002 · 4.4K citations · Full text

Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor

Michael C. Heinrich, Christopher L. Corless, George D. Demetri et al. · Journal of Clinical Oncology · 2003 · 2.3K citations

<i>PDGFRA</i> Activating Mutations in Gastrointestinal Stromal Tumors

Michael C. Heinrich, Christopher L. Corless, Anette Duensing et al. · Science · 2003 · 2.3K citations

Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor

Heikki Joensuu, Peter Roberts‎, Maarit Sarlomo‐Rikala et al. · New England Journal of Medicine · 2001 · 2.1K citations · Full text

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