RGD-recognizing integrins mediate interactions of human prostate carcinoma cells with endothelial cells in vitro

Abstract

Interactions of prostate carcinoma with endothelium are mediated in part via alpha5beta1, alpha3beta1, and alpha(v)beta3 integrins. Because these interactions are RGD-sensitive, synthetic RGD peptides with optimized flanking amino acids can potentially be used as antimetastatic agents.

References

Page 1

	Year	Citations
[15] Libraries of peptides and proteins displayed on filamentous phage George P. Smith, Jamie K. Scott Methods in enzymology on CD-ROM/Methods in enzymology BiochemistryNatural SciencesPeptide EngineeringPeptide LibraryPeptide Synthesis	1993	772
Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion. Martin J. Humphries, Steven K. Akiyama, Akira Komoriya, The Journal of Cell Biology Cell AdhesionImmunologyPathologyCytoskeletonCellular Physiology	1986	440
CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium. Luca Piali, P. Hammel, Christoph Uherek, The Journal of Cell Biology Cell AdhesionImmunologyImmune RegulationBlood CellImmunologic Mechanism	1995	380
Toward cell–targeting gene therapy vectors: Selection of cell–binding peptides from random peptide–presenting phage libraries Michael A. Barry, William J. Dower, Stephen Albert Johnston Nature Medicine Gene TherapiesPhage LibrariesPeptide EngineeringPeptide LibraryGene Therapy Vectors	1996	339
Differential expression of extracellular matrix molecules and the alpha 6-integrins in the normal and neoplastic prostate. J. David Knox, Anne E. Cress, Virginia A. Clark, PubMed	1994	187
Interleukin 1 promotes tumor cell adhesion to cultured human endothelial cells. Elisabetta Dejana, Federico Bertocchi, Marina Bortolami, Journal of Clinical Investigation Cell AdhesionImmunologyImmunotherapyTumor BiologyInflammation	1988	149
Tumor cell-endothelial interactions. Increased adhesion of human melanoma cells to activated vascular endothelium. Gregory E. Rice, Michael A. Gimbrone, M P Bevilacqua PubMed	1988	136
Integrin ?6 expression in human prostate carcinoma cells is associated with a migratory and invasive phenotypein vitro andin vivo Isaac Rabinovitz, Ray B. Nagle, Anne E. Cress Clinical & Experimental Metastasis UrologyMedicineCancer GrowthCell-matrix InteractionProstatic Disease	1995	120
Characterization of integrin subunits, cellular adhesion and tumorgenicity of four human prostate cell lines Colette M. Witkowski, Isaac Rabinovitz, Raymond B. Nagle, Journal of Cancer Research and Clinical Oncology UrologyCell AdhesionIntegrin SubunitsCell-matrix InteractionProstatic Disease	1993	116
Lipofection-mediated immortalization of human prostatic epithelial cells of normal and malignant origin using human papillomavirus type 18 DNA. P.C. Weijerman, Josée J. König, Stephen T.C. Wong, PubMed Cancer-associated VirusHuman Papillomavirus VaccinesMedicineOncogenic AgentPathology	1994	105

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