Decreased β-amyloid _1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease

Abstract

Low levels of Abeta1-42 in CSF do not exclude a diagnosis of CJD. Decreased levels of Abeta1-42 in CSF can occur without beta-amyloid plaque formation in the brain. However, the underlying mechanism of this phenomenon must be elucidated.