Chiral Brønsted Acid Catalyzed Enantioselective Friedel–Crafts Reaction of Indoles and α‐Aryl Enamides: Construction of Quaternary Carbon Atoms

Abstract

S express: Quaternary carbon atoms are constructed in excellent yields with high enantioselectivities by a highly efficient chiral Brønsted acid catalyzed Friedel–Crafts reaction of indoles and α-aryl enamides (see scheme). The presence of H atoms on the N atoms of both the indole and enamide moieties is essential for the reaction to occur. The indole molecule attacks from the Re face to give S-configured products. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701067_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.