Concepedia

CD39 is a negative regulator of P2X7-mediated inflammatory cell death in mast cells

Marcel Kuhny, Thomas Hochdörfer, Cemil Korcan Ayata, Marco Idzko, Michael Huber

Cell Communication and Signaling · 2014 · 31 citations · 42 references

DOIFull text

Open access

Abstract

Our study demonstrates that the fine-tuned interplay between ATP and different surface molecules recognizing or modifying ATP can control inflammatory and cell death decisions.

References

42

The Cytolytic P <sub>2Z</sub> Receptor for Extracellular ATP Identified as a P <sub>2X</sub> Receptor (P2X <sub>7</sub> )

Annmarie Surprenant, Eric Kawashima, R. Alan North et al. · Science · 1996 · 1.7K citations

Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

Pablo Pelegrı́n, Annmarie Surprenant · The EMBO Journal · 2006 · 1.4K citations · Full text

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

Jon A. Hagar, Daniel A. Powell, Youssef Aachoui et al. · Science · 2013 · 1.2K citations · Full text

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

Ravi Malaviya, Teruo Ikeda, Elaine Ross et al. · Nature · 1996 · 1.1K citations

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Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

Hajime Karasuyama, Fritz Melchers · European Journal of Immunology · 1988 · 1.1K citations