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H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse

Knockout MouseNeurodegenerative DiseasesMolecular NeuroscienceDevelopmental BiologyAutophagyCell DeathDegenerative PathologySca3 Transgenic MouseNeuroprotectionMutant Ataxin-3-induced NeurodegenerationMolecular NeurobiologyMedicineCell BiologyCell SignalingRock-inhibiting EffectNeurogenetics