Concepedia

Rac1 activates HIF-1 in retinal pigment epithelium cells under hypoxia

Peng Zhang, Xing Zhang, Xiaofeng Hao, Yusheng Wang, Yan-Nian Hui, Haiyan Wang, Dan Hu, Jian Zhou

Graefe s Archive for Clinical and Experimental Ophthalmology · 2009 · 36 citations · 30 references

DOI

Concepts

References

30

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

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Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

Navdeep S. Chandel, David S. McClintock, Carlos E. Feliciano et al. · Journal of Biological Chemistry · 2000 · 1.9K citations · Full text

, , +17

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

Gregg L. Semenza, Bing‐Hua Jiang, Sandra W. Leung et al. · Journal of Biological Chemistry · 1996 · 1.8K citations · Full text

, , +15

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

Hua Zhong, Kelly A. Chiles, David M. Feldser et al. · PubMed · 2000 · 1.5K citations

, , +17

Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains

Danqun Guo, Qing Jia, Ho-Yeong Song et al. · Journal of Biological Chemistry · 1995 · 481 citations · Full text

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