A Practical and Enantioselective Approach to Tetrahydrocarbazoles by Asymmetric Organocatalysis

Abstract

A highly enantioselective intramolecular Friedel–Crafts-type alkylation of ω-indolyl α,β-unsaturated aldehydes has been disclosed. This reaction allows efficient access to functionalized tetrahydrocarbazoles in high yields (up to 95 %) with excellent enantioselectivities (up to 98 % ee). This procedure is also successful in the asymmetric synthesis of pyrrole-fused heterocycles (up to 88 % ee). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.