Concepedia

Altered Na+/Ca2+-exchanger activity due to downregulation of Na+/K+-ATPase  2-isoform in heart failure

Fredrik Swift, J. A. K. Birkeland, Nils Tovsrud, Ulla Enger, Jan Magnus Aronsen, William E. Louch, I. Sjaastad, Ole M. Sejersted

Cardiovascular Research · 2008 · 89 citations · 30 references

DOI

Abstract

Downregulation of the alpha2-isoform causes attenuated control of NCX activity in CHF, reducing its capability to extrude Ca2+ from cardiomyocytes.

References

30

Sodium Current-Induced Release of Calcium from Cardiac Sarcoplasmic Reticulum

Normand Leblanc, Joseph R. Hume · Science · 1990 · 558 citations

, , +12

Orphaned ryanodine receptors in the failing heart

Long‐Sheng Song, Eric A. Sobie, Stacey L. McCulle et al. · Proceedings of the National Academy of Sciences · 2006 · 445 citations · Full text

Identification of a Specific Role for the Na,K-ATPase α2 Isoform as a Regulator of Calcium in the Heart

Paul F. James, I L Grupp, Günter Grupp et al. · Molecular Cell · 1999 · 382 citations · Full text

, , +15

The Relationship Between Charge Movements Associated with <i>I</i> <sub>Ca</sub> and <i>I</i> <sub>Na-Ca</sub> in Cardiac Myocyte

John H.B. Bridge, John R. Smolley, Kenneth W. Spitzer · Science · 1990 · 272 citations

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T‐tubule disorganization and reduced synchrony of Ca<sup>2+</sup> release in murine cardiomyocytes following myocardial infarction

William E. Louch, Halvor K. Mørk, Joseph Sexton et al. · The Journal of Physiology · 2006 · 253 citations · Full text

, , +21