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A Modified Triester Method for the Synthesis of Deoxyribopolynucleotides
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1973
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Combinatorial ChemistryDna NanotechnologyMedicinal ChemistryNucleic Acid ChemistryBioorganic ChemistryBiochemistryNatural SciencesOligonucleotideSynthetic BiologyMolecular BiologyModified Triester MethodDna Computing
A modified triester method has been developed for the synthesis of oligonucleotides starting from mononucleosides as more economical starting materials. A pentadecanucleotide has been successfully prepared.