Peptide Nucleic Acids (PNAs) Containing Thymine Monomers Derived from Chiral Amino Acids: Hybridization and Solubility Properties of <scp>D</scp>‐Lysine PNA

Abstract

Functionalized chiral D- and L-amino acids in peptide nucleic acids (PNAs; backbone of a PNA shown on the right) affect their solubility properties as well as their hybridization with DNA and RNA. Mismatched base pairs are discriminated by these new PNAs better than by glycine PNAs. Monomers may find application in amide-based combinatorial chemistry, PNAs in the pharmokinetic field and in the synthesis of DNA conjugates.