Concepedia

Publication | Closed Access

A Biliary HCO3 − Umbrella Constitutes A Protective Mechanism Against Bile Acid–Induced Injury in Human Cholangiocytes

DOI

306

Citations

41

References

2011

Year

Simon Hohenester, Lucas J. Maillette de Buy Wenniger, Coen C. Paulusma, Sandra J. van Vliet, Douglas M. Jefferson, Ronald P.J. Oude Elferink, Ulrich Beuers
Hepatology

Abstract

A biliary HCO3- umbrella protects human cholangiocytes against damage by bile acid monomers. An intact glycocalyx and adequate AE2 expression are crucial in this process. Defects of the biliary HCO3- umbrella may lead to the development of chronic cholangiopathies.

References

YearCitations

Page 1