Prognostic Significance of <i>MMP-1</i> and <i>MMP-3</i> Functional Promoter Polymorphisms in Colorectal Cancer

Abstract

In the subgroups of nondistant metatastic patients (stages I and II, and stages I-III), an inverse relation between the number of MMP-1-1607insG allele and survival was observed suggesting a gene dosage effect. Our results are consistent with the importance of MMP-1-1607ins/delG functional polymorphism in regulating transcription level and with the relationship between MMP-1 expression and cancer invasion, metastasis, and prognosis.