Regulatory Role of Interleukin–10 and Interferon-γ in Severe Hepatic Central and Peripheral Fibrosis in Humans Infected with<i>Schistosoma japonicum</i>

Abstract

IL-10 is associated with protection against central fibrosis, because of its anti-inflammatory and antifibrosis effects. IFN-gamma is associated with protection against PerF, which depends more on egg load and egg-associated toxicity.