Concepedia

A New Route to Highly Functionalized Heterocyclic Rings

Philip J. Parsons, Alexander J. Waters, Daryl S. Walter, Johnathan Board

The Journal of Organic Chemistry · 2007 · 31 citations · 32 references

DOI

Concepts

Abstract

A novel cascade reaction has been developed for the rapid construction of heterocyclic rings. The cyclization is thermally induced and does not involve the use of metal ions. This highly efficient construction of furans has been developed during studies directed toward the synthesis of the antibiotic lactonamycin 1.

References

32

Cobalt‐Mediated [2 + 2 + 2]‐Cycloadditions: A Maturing Synthetic Strategy [New Synthetic Methods (43)]

K. Peter C. Vollhardt · Angewandte Chemie International Edition in English · 1984 · 784 citations · Full text

, , +11

p-Benzyne. Generation as an intermediate in a thermal isomerization reaction and trapping evidence for the 1,4-benzenediyl structure

Richard R. Jones, Robert G. Bergman · Journal of the American Chemical Society · 1972 · 663 citations

, , +14

Iron-Catalyzed [2π + 2π] Cycloaddition of α,ω-Dienes:  The Importance of Redox-Active Supporting Ligands

M.W. Bouwkamp, A.C. Bowman, Emil B. Lobkovsky et al. · Journal of the American Chemical Society · 2006 · 331 citations

, , +14

Enantioselective Synthesis of Axially Chiral Anilides through Rhodium-Catalyzed [2+2+2] Cycloaddition of 1,6-Diynes with Trimethylsilylynamides

Ken Tanaka, Kenzo Takeishi, Keiichi Noguchi · Journal of the American Chemical Society · 2006 · 240 citations

, , +12

Stereospecific total synthesis of gibberellic acid. A key tricyclic intermediate

E. J. Corey, Rick Danheiser, Srinivasan Chandrasekaran et al. · Journal of the American Chemical Society · 1978 · 202 citations

, , +15