Concepedia

Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase

Tingting Sun, Nicola Aceto, Kristen L. Meerbrey, Jessica D. Kessler, Chunshui Zhou, Ilenia Migliaccio, Don X. Nguyen, Natalya N. Pavlova, Maria F. Botero, Jian Huang,

Cell · 2011 · 275 citations · 31 references

Open access

Concepts

MedicineMolecular BiologyOncologyCell SignalingMolecular OncologySignal TransductionCancer Cell SignalingOncogene ActivationProtein Kinase CascadesProtein Phosphatase SignalingProto-oncogene ActivationSignal Transduction In CancerPhosphatase InhibitionPhosphatase Signaling PathwaysPhosphatase TargetsPhosphorylation CascadesReceptor Protein Tyrosine PhosphatasesReceptor Tyrosine Kinase ActivationTyrosine Phosphorylation Signaling

References

31

Cancer Statistics, 2008

Ahmedin Jemal, Rebecca L. Siegel, Elizabeth Ward et al. · CA A Cancer Journal for Clinicians · 2008 · 10.2K citations · Full text

Medicine, Oncology, Cancer Epidemiology +16

Studies of the HER-2/ <i>neu</i> Proto-Oncogene in Human Breast and Ovarian Cancer

Dennis J. Slamon, William Godolphin, Lovell A. Jones et al. · Science · 1989 · 6.9K citations

Medicine, Molecular Biology, Oncology +15

<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Jing Li, Clifford Yen, Danny Liaw et al. · Science · 1997 · 4.8K citations

Medicine, Molecular Genetics, Oncology +16

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

Lee P. Lim, Nelson C. Lau, Philip W. Garrett-Engele et al. · Nature · 2005 · 4.8K citations

Life Sciences, Molecular Biology, Molecular Genetics +16

The landscape of somatic copy-number alteration across human cancers

Rameen Beroukhim, Craig H. Mermel, Dale Porter et al. · Nature · 2010 · 4.1K citations · Full text

Medicine, Genetics, Molecular Genetics +14