Angewandte Chemie International Edition · 2009 · 156 citations · 32 references
PharmacyOncologyPharmaceuticsDrug DeliveryNanoparticle Drug DeliveryTargeted Drug DeliveryCancer Drug DeliveryNanomaterials For Drug DeliveryNucleic Acid DeliveryQuantum DotsRna InterferenceSmall Interfering Rna DeliveryGene Delivery NanoparticlesQuantum Dot Drug DeliveryRna Delivery SystemsSmall Interfering Rna (Sirna) ChemistryTargeted BioimagingTargeted DeliveryTargeted Delivery SystemsTumor-targeted Drug Delivery
More than one job: Quantum dots (QDs) conjugated with thiol-modified small interfering RNA (siRNA) were functionalized with thiol-modified RGD and HIV-Tat peptides. These multifunctional QDs were used for the targeted delivery and tracking of siRNA molecules for the knockdown of the EGFRvIII gene, which led to the down-regulation of the PI3K-Akt signaling pathway and the apoptosis of malignant brain cancer cells.
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Probing the Cytotoxicity of Semiconductor Quantum Dots
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Cytotoxicity of Colloidal CdSe and CdSe/ZnS Nanoparticles
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Medicine, Oncology, Pharmaceutics +17