Concepedia

Impact of a Single Intracoronary Administration of Adiponectin on Myocardial Ischemia/Reperfusion Injury in a Pig Model

Kazuhisa Kondo, Rei Shibata, Kazumasa Unno, Masayuki Shimano, Masakazu Ishii, Tetsutaro Kito, Satoshi Shintani, Kenneth Walsh, Noriyuki Ouchi, Toyoaki Murohara

Circulation Cardiovascular Interventions · 2010 · 88 citations · 33 references

DOIFull text

Open access

Abstract

These data suggest that adiponectin protects against I/R injury in a preclinical pig model through its ability to suppress inflammation, apoptosis, and oxidative stress. Administration of intracoronary adiponectin could be a useful adjunctive therapy for acute myocardial infarction.

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