Friedländer synthesis of polysubstituted quinolines and naphthyridines promoted by propylphosphonic anhydride (T3P®) under mild conditions

Abstract

A new convenient, efficient and environmentally eco-friendly protocol for Friedländer synthesis of polysubstituted quinolines and naphthyridines is described. A wide variety of new products were readily prepared in the presence of propylphosphonic anhydride (T3P®) in short reaction times and excellent yields under mild conditions.

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