Potent and selective PKC inhibitory 5-membered ring analogs of balanol with replacement of the carboxamide moiety

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

Marco Castagna, Yoshimi Takai, Kozo Kaibuchi et al. · Journal of Biological Chemistry · 1982 · 4.8K citations · Full text

Life Sciences, Biochemistry, Cell Biology +16

Balanol: a novel and potent inhibitor of protein kinase C from the fungus Verticillium balanoides

Palaniappan Kulanthaivel, Yali F. Hallock, Christie Boros et al. · Journal of the American Chemical Society · 1993 · 213 citations

Life Sciences, Biochemistry, Pharmacology +8

Total Synthesis of Balanol

K. C. Nicolaou, Mark E. Bunnage, Kazunori Koide · Journal of the American Chemical Society · 1994 · 113 citations

Natural Sciences, Chemistry, Analytical Chemistry +5

Trans‐activation of HIV‐1 LTR‐directed gene expression by tat requires protein kinase C.

Aya Jakobovits, A S Rosenthal, Daniel J. Capon · The EMBO Journal · 1990 · 89 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +8

Total Synthesis of (-)-Balanol

John W. Lampe, Philip F. Hughes, Christopher K. Bíggers et al. · The Journal of Organic Chemistry · 1994 · 89 citations

Natural Sciences, Chemistry, Analytical Chemistry +6