Pak1 Is Required to Maintain Ventricular Ca ²⁺ Homeostasis and Electrophysiological Stability Through SERCA2a Regulation in Mice

Abstract

These findings indicate that Pak1 is required to maintain ventricular Ca(2+) homeostasis and electrophysiological stability and implicate Pak1 as a novel regulator of cardiac SERCA2a through a transcriptional mechanism.