Single-Cell Sequencing of the Healthy and Diseased Heart Reveals Cytoskeleton-Associated Protein 4 as a New Modulator of Fibroblasts Activation

Monika M Gladka, Bas Molenaar, Hesther de Ruiter, +7

Circulation

Pak1 as a Novel Therapeutic Target for Antihypertrophic Treatment in the Heart

Wei Liu, Min Zi, Ronald Naumann, +13

Circulation

A Novel Immunomodulator, FTY-720 Reverses Existing Cardiac Hypertrophy and Fibrosis From Pressure Overload by Targeting NFAT (Nuclear Factor of Activated T-cells) Signaling and Periostin

Wei Liu, Min Zi, Hoyee Tsui, +15

Circulation Heart Failure

Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy

Eirini Kyriakopoulou, Daniëlle Versteeg, Hesther de Ruiter, +13

Nature Cardiovascular Research

Mkk4 Is a Negative Regulator of the Transforming Growth Factor Beta 1 Signaling Associated With Atrial Remodeling and Arrhythmogenesis With Age

Laura Davies, Jiawei Jin, Weijin Shen, +16

Journal of the American Heart Association

Targeted deletion of ERK2 in cardiomyocytes attenuates hypertrophic response but provokes pathological stress induced cardiac dysfunction

Susanne Ulm, Wei Liu, Min Zi, +8

Journal of Molecular and Cellular Cardiology

Pak1 Is Required to Maintain Ventricular Ca ²⁺ Homeostasis and Electrophysiological Stability Through SERCA2a Regulation in Mice

Yanwen Wang, Hoyee Tsui, Yunbo Ke, +11

Circulation Arrhythmia and Electrophysiology

Desmosomal protein degradation as an underlying cause of arrhythmogenic cardiomyopathy

Hoyee Tsui, Sebastiaan J. van Kampen, Su Ji Han, +24

Science Translational Medicine

Smad3 Couples Pak1 With the Antihypertrophic Pathway Through the E3 Ubiquitin Ligase, Fbxo32

Hoyee Tsui, Min Zi, Shunyao Wang, +7

Hypertension

Stress-Activated Kinase Mitogen-Activated Kinase Kinase-7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention

Sanjoy K. Chowdhury, Wei Liu, Min Zi, +20

Circulation