c-Cbl Inhibition Improves Cardiac Function and Survival in Response to Myocardial Ischemia

Abstract

c-Cbl activation promotes myocyte apoptosis, inhibits angiogenesis, and causes adverse cardiac remodeling after myocardial infarction. These findings point to c-Cbl as a potential therapeutic target for the maintenance of cardiac function and remodeling after myocardial ischemia.