A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy

Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates:  Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitro Anticancer Activity

Gene M. Dubowchik, Raymond A. Firestone, Linda Padilla et al. · Bioconjugate Chemistry · 2002 · 546 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Global Profiling of the Cell Surface Proteome of Cancer Cells Uncovers an Abundance of Proteins with Chaperone Function

Bong Kyung Shin, Hong Wang, Anne Marie Yim et al. · Journal of Biological Chemistry · 2003 · 521 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy.

Chengzao Sun, Haining Huang, Kim D. Janda et al. · PubMed · 2003 · 340 citations

Pharmacy, Oncology, Pharmacology +17

Synthesis and Biological Evaluation of Dimeric RGD Peptide−Paclitaxel Conjugate as a Model for Integrin-Targeted Drug Delivery

Carmen Plasencia, Yingping Hou, Nouri Neamati · Journal of Medicinal Chemistry · 2005 · 253 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Targeting Heat Shock Proteins on Cancer Cells:  Selection, Characterization, and Cell-Penetrating Properties of a Peptidic GRP78 Ligand

Young Soo Kim, Antonietta M. Lillo, Sebastian C.J. Steiniger et al. · Biochemistry · 2006 · 188 citations

Pharmacy, Molecular Biology, Oncology +16