Interleukin-15 as an Immune Adjuvant To Increase the Efficacy of <i>Mycobacterium bovis</i> Bacillus Calmette-Guerin Vaccination

Masayuki Umemura, Hitoshi Nishimura, Kimika Saito, Toshiki Yajima, Goro Matsuzaki, Satoru Mizuno, Isamu Sugawara, Yasunobu Yoshikai

Infection and Immunity · 2003 · 35 citations · 13 references

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Abstract

Interleukin-15 (IL-15) transgenic mice which had been inoculated with Mycobacterium bovis bacillus Calmette-Guérin (BCG) 24 weeks previously showed resistance against airborne infection with Mycobacterium tuberculosis H37Rv accompanied by an increased CD8(+)-Tc1-cell response. IL-15 may be used as an immune adjuvant given with BCG vaccination to enhance its biologic efficacy.

References

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