Assessment of Large-Vessel Involvement in Giant Cell Arteritis with ¹⁸F-FDG PET: Introducing an ROC-Analysis–Based Cutoff Ratio

Abstract

The (18)F-FDG PET region-of-interest analysis with aorta-to-liver maximal standardized uptake value ratios is a reliable, investigator-independent indicator of GCA not affected by minor inflammation-associated changes in hepatic metabolism. Our results for a cutoff ratio of 1.0 prove that (18)F-FDG PET is a method of high sensitivity and specificity for GCA-related large-vessel inflammation.